Overview

SPI is focused on developing therapeutics to address patients with significant unmet medical needs in the space of sensorineural otologic diseases.

For additional details of SPI’s clinical trials, please follow the link to Clinicaltrials.gov

Our Product Pipeline

Indication
Therapeutic Candidate

  • Preclinical
  • Phase 1
  • Phase 2
  • Phase 3

Acute NIHL
Mild to Moderate

SPI-1005

(Phase 2)

Title

70%

Click for Status

SPI-1005 reduced the incidence and severity of NIHL,

published in The Lancet – July 2017

For more information regarding ongoing or upcoming studies see Clinicaltrials.gov

Meniere’s Disease
SPI-1005

(Phase 2)

Title

80%

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Phase 2 Meniere’s Disease clinical trial completed with positive topline results

 

For more information regarding ongoing or upcoming studies see Clinicaltrials.gov

Chemotherapy-Induced Ototoxicity
SPI-3005

(Phase 1)

Title

50%

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For more information regarding ongoing or upcoming studies see Clinicaltrials.gov

Aminoglycoside-Induced Ototoxicity
SPI-3005

(Phase 1)

Title

50%

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Phase 1b STOP Ototoxicity study completed,

see presentation at 2018 NACFC

A phase 2 study to test the safety and tolerability of SPI-1005 in people with cystic fibrosis is currently underway.  Details here.

For more information regarding ongoing or upcoming studies see Clinicaltrials.gov

Severe to Profoundly
Impaired

SPI-5557

(Phase 1)

Title

20%

Click for Status

IND yet to be filed

Our Product Pipeline